Hair loss, Alopecia, Androgenetic Alopecia

Alopecia is a common disorder affecting more than half of the population worldwide. Androgenetic alopecia, the most common type, affects 50% of males over the age of 40 and 75% of females over 65.

Source: National Institute of Health

Two thirds of men suffer with hair loss by the age of 35 and by the age of fifty approximately 85% of men have significantly thinning hair. 40% of hair loss sufferers are women.

Source: American Hair Loss Association

 

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Proven Benefits of PhotoBioStimulation (PBS), Low Level Laser Therapy (LLLT)

Laser Hair Therapy (LHT)

  • Fuller, thicker, shinier, and healthier hair with fewer hair loss treatments
  • All-natural hair therapy that is completely safe and produces zero side effects
  • Portable LHT is convenient – used at any time, any place; which increases patient compliance
  • Greater confidence and a better appearance with a device that combats common hair loss, including male pattern baldness, some hormonal imbalances, diet and stress

“PhotoBioStimulation (PBS), commonly referred to as laser hair therapy or light therapy, is an FDA cleared safe and effective treatment to stop hair loss and help regrow hair.”

-Dr. Robert Haber, Dermatologist, renowned hair transplant surgeon and recipient of ISHRS Golden Follicle Award

“Laser Hair Therapy is by far the most advanced and promising non-surgical hair loss treatment available today for men and women.”

-Dr. Bradley Kurgis, Dermatologist and diplomate of the American Board of Hair Restoration Surgery

“LLLT is a safe, non-invasive treatment for men and women experiencing hair loss. Low Level Laser therapy technology harnesses light energy and emits it from a laser diode that penetrates the scalp and invigorates the cells, which delivers nutrients and oxygen to hair follicles. By stimulating cell metabolism and reducing the harmful effects of dihydrotestosterone (“DHT”), the laser light has been found to slow hair loss and to help new hair growth, making the technology one of the most sought after hair loss solutions throughout the world.”

-Dr. Michael Hamblin, Assoc. Professor of Dermatology at Harvard Univ., Chief Investigator of Photomedicine at The Wellman Center for Photomedicine at Harvard Medical School

 

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Mechanisms of Laser-Induced Hair Regrowth, Optimal LLLT

Dr. Michael Hamblin is an Associate Professor of Dermatology at Harvard University and Chief Investigator of Photomedicine of the Wellman Center for Photomedicine at Harvard Medical School. He outlines what was found, and many peers agree, is “optimal LLLT” in his “Mechanisms of laser-induced hair regrowth” published research. In summary, he describes the mechanism of low level laser light therapy as affecting the growth of cells in the scalp, of which the hair cells are a key part:

  1. As DHT is the agent in the body that blocks cell growth, LHT is thought to open the pathways to the cells, increasing microcirculation of blood and allowing the cells to take in nutrients and release toxins. This process is necessary to reverse “miniaturization” of hair follicles by allowing cells to grow and replicate.
  1. Another bi-product of LHT, as witnessed in clinical studies, is an increase in the body and fullness of hair follicles being treated. This is believed to be caused by the stimulation of the arector pili muscle-a tiny muscle found in every hair or follicular unit. The arector pili muscle is what gives hair support. Stimulated by LHT, the hair tends to regain its former support, providing lift to the hair.
  1. Finally, the shine, luster and elasticity of the hair follicle are affected by the output of the sebaceous gland, the lubricating agent that allows the hair to penetrate the scalp. Clients of LHT often find their hair becoming shinier and more flexible, as opposed to dry and brittle. The effect of LHT on the sebaceous gland is thought to normalize the gland.

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History

The benefits of Low Level Laser Light Therapy (“LLLT”) were first reported in the late 1960’s by Hungarian scientist Andre Mester, who observed the rapid healing and re-growth of hair on mice that were irradiated with LLLT.

 

The scientific term for the process is called “PhotoBioStimulation” (PBS). The four distinct effects of PBS are:

  • An increase in ATP (Adenosine Triphosphate) and protein synthesis,
  • Improved cell proliferation,
  • A change in cell membrane permeability, and
  • Increased blood circulation due to the dilation effect of the Low Level Laser Light Therapy on capillaries.

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LLLT Treats Thinning Hair

Low level laser therapy (LLLT) has been shown in dozens of peer-reviewed publications to increase cellular survival, proliferation and function. The light is absorbed by mitochondria, increases cellular respiration and induces activation of transcription factors via reactive oxygen species.

 

LLLT and FDA

Low Level Laser Light reaches the dermal layer that contains the hair follicle.  FDA regulations require that no more than 5mW of energy per diode can be produced by hair therapy devices. Described as “cool lasers”, they penetrate the scalp to the depth of the major blood supply or < 10mm.

Ultimately, the effect of LLLT is to help hair return to normal growth cycle.  Laser Hair Therapy (LHT) stimulate cellular respiration, the absorption of nutrients and the release of toxins through the mitochondria of the hair cells.

 

Regular use improves restoration

Maintaining a proper regimen of use maximizes the effect of LHT.  Often compared to building muscle with exercise, “stacking” energy delivered to the cells can create a prolonged and lasting effect on the production of hair cells. By contrast, like over-stimulating the same muscle group with daily exercise, it is often recommended to use LLLT on alternate days.

 

Studies Regarding Laser Hair Therapy

 

In Oct of 2003 an ISHRS.org (International Society of Hair Restoration Surgeons) Press Release regarding clinical study results of an LHT hand held device was submitted to the FDA. Dr. Martin Unger of Toronto reported. The results were summarized:

  • 100% of men had stabilization of hair loss in frontal and vertex (top of the head) areas;
  • 6% of men had hair regrowth (11% of more from baseline) in the frontal area;
  • 8% of men had hair regrowth (11% or more from baseline) in the vertex area;
  • 5% of women had stabilization of hair loss in the frontal area;
  • 100% of women had stabilization of hair loss in the vertex area;
  • 75% of women had hair regrowth (11% or more from baseline) in the frontal area; and,
  • 4% of women had hair regrowth (11% or more from baseline) in the vertex area.

Source: ISHRS.org

 

In 2010, the FDA granted marketing clearance to a hand-held laser device, which reported, in summary, subjects results.

  • 97% demonstrated an increased hair count of 20%
  • 89% demonstrated an increased hair count of 30%
  • 57% demonstrated an increased hair count of 50%

Source: MidwestRF.com

 

Laser Surg Medical, 2014

This review surveys the evidence for low-level laser therapy (LLLT) applied to the scalp as a treatment for hair loss and discusses possible mechanisms of actions.

Results: Studies have shown that LLLT stimulated hair growth in mice subjected to chemotherapy-induced alopecia and also in alopecia areata. Controlled clinical trials demonstrated that LLLT stimulated hair growth in both men and women. Among various mechanisms, the main mechanism is hypothesized to be stimulation of epidermal stem cells in the hair follicle bulge and shifting the follicles into anagen phase.

Source: National Institutes of Health

 

American Journal of Clinical Dermatology, 2014

Randomized, double-blind multi-center study (including Harvard, MIT, Cleveland Clinic)

Result: Statistically significant improvement in hair density in the treatment group. Hair shafts were both more numerous as well as thicker in about 95% of the treatment group. No significant negative side effects.

Source: American Journal of Clinical Dermatology